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1 Chapter 1: Full Strategy List (Alphabetical)

Organizing Frameworks

Organizing frameworks provide a structured overall approach for planning, implementing, and evaluating communities’ substance use prevention and mental health promotion efforts. These frameworks offer systematic processes that guide stakeholders through key steps, from assessing community needs to measuring outcomes. Three prominent frameworks in this field are Communities That Care (CTC), the Strategic Prevention Framework (SPF), and the Whole School, Whole Community, Whole Child (WSCC) model.

These frameworks provide communities with roadmaps for organizing comprehensive, evidence-based prevention and promotion initiatives. They share common elements such as community engagement, data-driven planning, and ongoing evaluation, while each offering unique strengths and emphases.

Strategy Evidence-Based Registry or Research

Communities That Care

Societal Unit of Practice

Communities That Care (CTC) is a coalition-based prevention system that uses a public health approach to prevent youth problem behaviors. It is notable for being the only framework with randomized controlled trial (RCT) evidence supporting its effectiveness. CTC guides communities through a five-phase process to identify risk and protective factors, select evidence-based interventions, and monitor outcomes.

Conduent/CDC (Evidence Based): CTC

Blueprints (Promising): CTC

Crime Solutions (Promising): CTC 

SAMHSA: CTC

Strategic Prevention Framework

The Strategic Prevention Framework (SPF) is a five-step planning process developed by the Substance Abuse and Mental Health Services Administration (SAMHSA). It emphasizes data-driven decision making, capacity building, and sustainability in prevention efforts. The SPF is widely used in substance abuse prevention initiatives across the United States.

Sage: SPF

Science Direct: SPF

Wiley: SPF

Whole School, Whole Community, Whole Child

The Whole School, Whole Community, Whole Child (WSCC) model, developed by the Centers for Disease Control and Prevention (CDC) and Association for Supervision and Curriculum (ASCD), takes a holistic approach to child development and learning. The model focuses on the student and emphasizes the collaboration between schools, communities, public health, and health care sectors to align resources in support of the whole child.

While not specific to substance use prevention, it integrates health promotion, through the Characteristics of an Effective Health Education Curriculum into the overall educational environment, recognizing the interconnectedness of physical and mental health with academic achievement.

NIH: WSCC

Walden: WSCC

The alphabetized table below supplies information for various evidence-based prevention strategies. The table includes the name of a strategy, along with its respective target populations, domains, links to registries, and information on research or peer review. The Compendium is updated regularly to reflect the most recent status of evidence-based strategies available to prevention practitioners. Every effort is made to provide timely and comprehensive listings. Please note, however, that programs, practices, and policies are added and removed from registries and given peer reviews on an ongoing basis. For this reason, the Compendium may not represent the total sum of strategies available at any given time. If you know of an evidence-based strategy that we should consider including, please contact us with details at tahelp@iu.edu.

Through assessing your community, you have learned that there are contributing factors (determinants, risk factors) for substance misuse. When researching programs and practices, look for aspects such as geography, program effectiveness, target demographics, setting, and program type that align with your pre-selected determinants. Evidence-based registries and research articles will often give information on where and who the target population was during evaluation. Matching your target population to the geography (rural, urban, suburban), the demographics of the population that was served, and where the intervention was held can help create a successful project with consistently superior program fidelity.

Table Columns:

  • Strategy Name and Links to the Program Website. Clicking on the name will take you to the developer’s website.
  • Focus Population is based on the subpopulation the strategy is designed to reach. More information on focus population can be found in Chapter 3.
  • Domain is a way to identify the best reach for different contributing (risk and protective) factors which impact behavior. Details on Domains can be found in Chapter 4.
  • IOM Category identifies the most appropriate delivery method for the strategy. Details on IOM Categories can be found in Chapter 5.
  • Setting lists the location types for effective delivery.
  • CSAP Strategy type provides information on the type of strategy. Additional CSAP Strategy information is in Chapter 6.
  • Tier Level are based on level of evaluation effectiveness. Evidence of Effectiveness based on evaluation criteria can be found in Tier Level details in Chapter 2.
  • Evidence-Based Registry or Research provides links to the evaluation results or peer reviewed articles that support evaluation. Those registries used to rate the programs will also show the determined level of effectiveness such as “Promising” or “Effective.”

*Strategies marked with an asterisk (*) have been proven effective for other behaviors (See chapter 7)

Strategy Focus Population Domain IOM Setting CSAP Strategy Type Tier Level Evidence-Based Registry or Research
Advertising Restrictions
Youth Community Universal Indirect Other Environmental Approach Tier 2 County Health Rankings (Some Evidence): AR

Athena Forum: AR

SAMHSA: AR

Alcohol EDU
College through age 30 Individual Universal Direct Campus Education Tier 1 CollegeAIM (Higher Effectiveness): AE

NIH: AE

Alcohol Literacy Challenge
High School, College

Suburban

Individual Universal Direct School

Campus

Education Tier 2 Crime Solutions (Promising): ALC
Al’s Pals: Kids Making Healthy Choices *
Pre-K, Elementary

Urban/Suburban

Individual

School

Universal Direct School Education Tier 1 Conduent/CDC (Evid.-Based): AlP

Crime Solutions (Promising): AlP

All Stars* (All Stars Core Program)
6th grade Individual Universal Direct School Education Tier 1 CEBC (Promising): All Stars

Sage: All Stars

Sage: All Stars

OASAS: All Stars

Crime Solutions: Ineffective

Alternative Events and Activities

Substance Free Alternative Events (SFAE), Alternative Community Events (ACE) Framework, Community Alternative Resiliency Events (CARE)

All Populations

Community

Universal Indirect

Community Information Dissemination

Alternatives

Community-Based Process

Tier 2 National Crime Prevention Council: Alternatives

Wiley: Alternatives

OJP: Alternatives

ScienceDirect: Alternatives

SAMHSA (alternatives: effective): Alternatives

Baby and Me Tobacco Free
Pregnant and New Mothers Family Selective Other Education Tier 1 Wiley: BMTF

Springer: BMTF

AAP: BMTF

Bienvenido*
Young Adults, Adults, Older Adults, Unique Population (Hispanic) Individual Selective Other Education Tier 2 Stanford: Bienvenido
Big Brothers Big Sisters*
Elementary, Middle School, High School Individual

Community

Family

Selective Other

Community

Education

Mentoring

Tier 1 Crime Solutions (Effective): BBBS

Blueprints (Promising): BBBS

Blues Programs*
High School Individual Selective

Indicated

School Education Tier 1 Conduent/CDC (Evid.-Based): BP

Blueprints (Model): BP

Cannabis eCHECKUP TO GO
College Individual Indicated School

Online

Education Tier 2 Blueprints (Promising): CETG
Caring School Community*
Elementary, Middle School School Universal Direct School Education Tier 2 Crime Solutions (Promising): CSC

CASEL (Select): CSC

CATCH My Breath
Middle, High School School Universal Direct School Education Tier 1 Eastern Carolina Univ: CMB

NIH: CMB

Sage: CMB

Science Direct: CMB

College Age Social Norms Campaign

Examples: Challenging College Alcohol Abuse, Buzzkill

College Individual

School

Universal Indirect School Information Dissemination Tier 2 County Health Rankings (Some Evidence): CASN

NIAAA: CASN

Communities Mobilized  for a Change on Alcohol (CMCA)
Young Adult Community Universal Indirect Other Community-Based Process Tier 2 CH Military Fam.: CMCA

CEBC (Promising): CMCA

Wiley: CMCA

SAMHSA: CMCA

Coping Power*
Elementary

Urban, Suburban

Individual

School

Family

Universal

Selective

School Education Tier 1 Conduent/CDC (Evid.-Based): CP

Blueprints (Promising): CP

Crime Solutions (Promising): CP

SAMHSA: CP

Creating Lasting Family Connections
Elementary, Middle, High School, Parents Family Universal Direct

Selective

Other Education Tier 1 Conduent/CDC (Evid.-Based): CLFC

NIH: CLFC

CEBC (Promising): CLFC

OASAS: CLFC

Curriculum Based Support Group (CBSG) Youth Connection*
Elementary, Middle School Individual

Family

Selective

Indicated

School

Community

Education Tier 2 Developer Evaluation: CBSG

Athena Forum: CBSG

Drug Take Back/Disposal
All Populations Community Universal Indirect Community Community-Based Process Tier 2 County Health Rankings (Expert Opinion): DTB
Familias Unidas*
Parents, Unique Populations

Hispanic, Latino

Individual

Family

Selective Home

Community

Education Tier 1 Blueprints (Promising): FaUm

Crime Solutions (Effective): FaUm

SAMHSA: FaUm

OASAS: FaUm

Families in Action* (Active Parenting)
Families

Rural

Family Universal Direct Other Education Tier 1 Conduent/CDC (Evid.-Based): FIA
Family Matters*
Middle School, Parents Individual

Family

Universal Direct Home Education Tier 2 Conduent/CDC (Effective): FM

CEBC (Supported): FM

Footprints for Life

Pre-K, Elementary

Individual

School

Universal Direct School Education Tier 1 Rutgers Evaluation: FFL

MW Journal: FFL

Good Behavior Game*

Elementary

Individual

School

Universal Direct School Education Tier 2 Crime Solutions (Promising): GBG

Blueprints (Promising): GBG

OASAS: GBG

Great Body Shop*

Pre-k-Middle School

Individual

School

Universal Direct School Education Tier 1 Conduent/CDC (Evid.-Based): GBS
Guiding Good Choices*

Elementary, Middle School, Parents

Individual

Family

Universal Direct Other Education Tier 1 Conduent/CDC (Evid.-Based): GGC

Blueprints (Promising): GGC

Crime Solutions (Effective): GGC

SAMHSA: GGCOASAS: GGC

InShape Prevention Plus Wellness

Early Adulthood

Rural/Frontier

Individual Universal Direct School Education Tier 2 Blueprints (Promising): InShape
keepin’ it REAL*

Middle School

Individual Universal Direct School Education Tier 1 Conduent/CDC (Evid.-Based): KIR

CEBC (Promising): KIR

OASAS: KIR

LifeSkills Training Program*

Elementary, Middle, High School

Individual Universal Direct School Education Tier 1 Conduent/CDC (Evid.-Based): LST

Blueprints (Model): LST

SAMHSA: LST

OASAS: LST

LifeSkills Transitions*

Upper High School

Individual Universal Direct School Education Tier 3 Similar to LifeSkills Training Program. No individual strategy research.
Linking the Interests of Families and Teachers (LIFT)

Early Elementary, Teachers, Parents

Urban

Children exposed to violence

Individual

School

Family

Indicated School Education Tier 1 Crime Solutions (Effective): LIFT

Military Fam. PSU (Promising): LIFT

Sage: LIFT

Lion’s Quest Skills for Growing*

Elementary

 

Individual

School

Family

Community

Universal Direct

School Education Tier 1 Conduent/CDC (Evid.-Based): LQS

Military Fam. PSU (Promising): LQS

CASEL (Promising): LQS

OASAS: LQS

Master Mind*

Upper Elementary

Rural

Individual Universal Direct School Education Tier 2 Crime Solutions (Promising): MM
Media Detective

Elementary

Suburban

Individual Universal Direct School Education Tier 1 Conduent/CDC (Evid.-Based): MD
Media Ready

Middle School

Suburban

Individual Universal Direct School Education Tier 2 Crime Solutions (Promising): MR
Michigan Model for Health*

Elementary, Middle, High School

Individual Universal Direct School Education Tier 1 Conduent/CDC (Evid.-Based): MMH

Crime Solutions (Promising): MMH

Model Smoking Prevention Program

Middle School

Individual Universal Direct School Education Tier 2 Crime Solutions (Promising): MSPP
Parent-Focused Positive Norms Campaign:

Examples: Talk. They Hear You., Parents Who Host Lose the Most

Family

Family Universal Indirect Parent & Community Information Dissemination Tier 2 CDC: PFC

NIH: PFC

NIH: PFC2

Policy Change

All Populations

Community Universal Indirect Community Environmental Approach Tier 2 NIH: PC

Wiley: PC

T&F: PC

Positive Action*

High School, Young Adult

School

Individual

Universal Direct School Education Tier 1 Blueprints (Model): PAct

Conduent/CDC (Evid.-Based): PAct

SAMHSA: PAct

OASAS: PAct

Positive Culture Framework (Positive Community Norms)

Montana Model (Most of Us), Population Focused Campaigns

All Populations

Community

School

Universal Indirect Other Information Dissemination Tier 2 Sage Publications: PCF

SpringerLink: PCF

PreVenture

Middle, High School

School

Individual

Universal Direct

Selective

School Education Tier 1 NIH: PV

NIH: PV

OASAS: PV

Prime for Life

Young Adults

Individual Universal

Selected

Indicated

Community Education Tier 2 Athena Forum: PFL

Crime Solutions: Inconclusive

Project Alert

Middle, High School

Individual Universal Direct School

Community

Education Tier 2 Rand: PAl

NIH: PAl

Crime Solutions (Ineffective): PAl

Project Northland and Class Action

Class Action is considered evidence informed when used as a booster to Project Northland

Middle School

Rural

Individual, School Universal Direct School

Community

Education Tier 2 Crime Solutions (Promising): PN

Athena Forum: Class Action

Project SUCCESS

Middle, High School

Rural/Frontier

Individual

Universal Direct

School

Community

Education Tier 2 Conduent/CDC (Effective): PS
Project Towards No Drug Abuse*

Middle School, High School, College

Individual

Universal Direct

Selective

School Education Tier 1 Conduent/CDC (Evid.-Based): PTND

Blueprints (Model): PTND

CEBC: PTND

OASAS: PTND

SAMHSA: PTND

Project Towards No Tobacco Use

Middle School, High School

Individual

Universal Direct

Selective

School Education Tier 2 Crime Solutions (Promising): TNT

NIH: TNT

SAMHSA: TNT

Project Venture

Indigenous People (American Indian Youth)

Individual

Selective

School

Community

Education Tier 2 OJP: PV

SAMHSA: PV

Raising Healthy Children*

Elementary, Middle, High School, Parents

Suburban

Individual

School

Family

Community

Universal Direct

School Education Tier 2 Blueprints (Promising): RHC

Crime Solutions (Promising): RHC

SAMHSA: RHC

Refuse, Remove, Reasons

High School

Urban, Suburban

Individual

Indicated

School Education Tier 1 ResearchGate (QED): RRR
SMART Leaders/Stay SMART

Components of SMART Moves

Middle School

Individual

Universal Direct

Other (Boys and Girls Clubs) Education Tier 2 Crime Solutions (Promising): SL

Harvard: SL

Modeled from Botvin’s LifeSkills. Strategy must contain Stay SMART to be considered promising and can also contain SMART Leaders.

SPORT Prevention Plus Wellness

High School

Individual

Universal Direct

School Education Tier 1 Conduent/CDC (Evid.-Based): SPPW

Blueprints (Promising): SPPW

OASAS: SPPW

SAMHSA: SPPW

STARS for Families

Middle, Early High School, Parent

Family

Universal Direct

Other Education Tier 2 Conduent/CDC (Effective): SFF

Crime Solutions (Ineffective): SFF

Staying Connected with Your Teen*

Middle, High School, Young Adult, Parent

Family

Universal Direct

Other Education Tier 2 Crime Solutions (Promising): SCYT
Strengthening Families Program*

Pre-K, Elementary, Middle, High School, Parents

Family

Universal Direct

Other Education Tier 2 Conduent/CDC (Effective): SF

Crime Solutions (Promising): SF

CEBC (Promising): SF

OASAS: SF

Strengthening Families Program 10-14*

Middle School, Parents

Family

Universal Direct

Other Education Tier 1 Conduent/CDC (Evid.-Based): SFP

CEBC (Well Supported): SFP

OASAS: SFP

SAMHSA: SFP

Strong African American Families*

Elementary, Middle School, Parents

African American

Family

Universal Direct

School

Other

Education Tier 2 Blueprints (Promising): SAAF

Crime Solutions (Effective): SAAF

SAMHSA: SAAF

Team Awareness*

Young Adult, Adult, Older Adult

Individual

Universal Direct

Workplace Education Tier 1 NIH: TA

SAMHSA: TA

Prevention Science: theoretical backing

Team Resilience*

Young Adult

Individual

Universal Direct

Other Education Tier 3 Similar to Team Awareness . No individual strategy research.
The Truth Campaign

Middle, High School

Community

Universal Indirect

Community Information Dissemination Tier 1 Crime Solutions (Promising): TC

NIH: TC (2004)

AJPM: TC (2010)

NIH: TC (2018)

Oxford Academic: TC (2022)

Too Good for Drugs

Elementary, Middle, High School

Individual

Universal Direct

School Education Tier 1 Conduent/CDC (Evid.-Based): TGFD

Study (Eval): TGFD

OASAS: TGFD

Too Good for Violence*

Mid-level Elementary, Middle, High School

Individual

Universal Direct

School Education Tier 1 Conduent/CDC (Evid.-Based): TGFV

Crime Solutions (Promising): TGFV

OASAS: TGFV

Wellness Initiative for Senior Education (WISE)*

Older Adults

Individual

Universal Direct

Other Education Tier 1 Conduent/CDC (Evid.-Based): WISE

NCOA: WISE

ACL: WISE

You and Me Together Vape Free, Stanford University

Elementary, Middle, High School

Individual, School

Universal Direct

School Education Tier 2 Wiley: YMTVF
Youth Positive Social Norms

Examples: Be the Majority, Above the Influence, What’s Your Side Effect?, Midwestern Prevention Project, The Real Cost

Elementary, Middle, High School

Community

Universal Indirect

Other Information Dissemination Tier 2 Crime Solutions (MPP-effective): YSN

SAMHSA (TRC, TTC): YSN

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DMHA Primary Prevention Substance Misuse Strategy Compendium Copyright © 2025 by Indiana University, Prevention Insights. All Rights Reserved.